Pentoxifylline: A Potent Inhibitor of Angiogenesis via Blocking STAT3 Signaling in B16F10 Melanoma
Year: 2013
Type: article
Abstract: Pento xifylline (PTX) has been shown to exert anti-metastatic activity in solid tumor. In the present study the underlying mo lecular mechanism of the anti- angiogenic activ ity of PTX was investigated in highly metastatic B16F10 melano ma. PTX suppressed the phosphorylation of Signal transducer activator of Transcription 3(STAT3) and its upstream kinases in B16f10 melano ma at nontoxic dosages. It also reduced the expression of HIF1α, VEGF (potent angiogenic factor), its receptors (VEGFR1, VEGFR2) and pro-inflammatory cytokines which play a significant role in induction of angiogenesis in solid tu mors. Moreover, PTX significantly suppressed the microvessel density around tumor induced in mice by injecting B16F10 cells intradermally on shaven ventral site. The inhibition in vasculature around tumor resulted in regression of tumor volume in PTX treated group of animals as compared to untreated group. These findings suggest that PTX exert anti-tu mor activity by inhibit ing angiogenesis via targeting the STAT3 signaling pathway in B16F10 melanoma
Authors: Pratibha Dhumale, Nikam Yuvraj, Gude Rajiv
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W151160302