Work

Molecular Cytogenetics: Genomic Imbalances in Colorectal Cancer and their Clinical Impact

Year: 2006

Type: article

Abstract: Chromosomal aberrations play a dominant role in colorectal carcinogenesis. The application of fluorescence in situ hybridization (FISH) based techniques such as comparative genomic hybridization (CGH) and spectral karyotyping (SKY) revealed that colorectal carcinomas are characterized by a specific pattern of chromosomal imbalances which sequentially accumulate during cancer progression. This review aims to summarize molecular cytogenetic studies, provides a background on the functional relevance of chromosomal aberrations for colorectal cancer progression and discusses their potential clinical impact.

Source: Analytical Cellular Pathology

DOI: 10.1155/2006/173815

Authors: Marian Grade, Heinz Becker, Torsten Liersch, Thomas Ried, B. Michael Ghadimi

Institutions: Universitätsmedizin Göttingen, National Institutes of Health, National Cancer Institute, Center for Cancer Research

Language: English

Topic: Genetic factors in colorectal cancer

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,160