Work

Reduced central white matter volume in autism: Implications for long‐range connectivity

Year: 2010

Type: article

Abstract: Cortical and central white matter (WM) volumes were measured to assess short- and long-range connectivity in autism, respectively. Subjects included 23 boys with autism and 23 matched controls, all without intellectual disability. Magnetic resonance imaging data obtained at 1.5 T were analyzed using BRAINS2 software (University of Iowa, Iowa City, IA, USA). Central WM volume was quantified by subtracting cortical from supratentorial WM volumes. Reduced central WM volume was observed in the autism group. IQ was higher in controls with no observed correlations between WM volumes and IQ. This preliminary evidence of reduced central WM volume in autism suggests abnormal long-range connectivity.

Source: Psychiatry and Clinical Neurosciences

DOI: 10.1111/j.1440-1819.2010.02164.x

Authors: Roger J. Jou, Natasa Mateljevic, Nancy J. Minshew, Matcheri S. Keshavan, Antonio Y. Hardan

Institutions: Yale University, University of Pittsburgh, Harvard University, Stanford Medicine, Stanford University

Language: English

Topic: Autism Spectrum Disorder Research

Subfield: Cognitive Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute of Mental Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development