Work

Manipulating Somatic Cells to Remove Barriers in Induced Pluripotent Stem Cell Reprogramming

Year: 2013

Type: dissertation

Abstract: Development leads unidirectionally towards a more restricted cell fate that is usually stable. However, it has been proven that developmental systems are reversible by the success of animal cloning of a differentiated somatic genome through somatic cell nuclear transfer (SCNT). Recently, reprogramming of somatic cells to a pluripotent embryonic stem cell (ESC)-like state by introducing defined transcripton factor has been achieved, resulting in the generation of induced pluripotent stem cells (iPSCs), which resemble ESCs. iPSC reprogramming is of great medical interest, as it has the potential to generate a source of patient-specific cells. However, the dangerous delivery method, low efficiency, and slow kinetics of the reprogramming process have hampered progress with this technology.

Source: Digital Access to Scholarship at Harvard (DASH) (Harvard University)

Author: Julia Eunyoung Chung

Language: English

Topic: Pluripotent Stem Cells Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: John D. and Catherine T. MacArthur Foundation, Alexander von Humboldt-Stiftung, Ministry of Education, Culture, Sports, Science and Technology, National Institutes of Health, Novartis Institutes for BioMedical Research, Japan Society for the Promotion of Science, National Institute of General Medical Sciences, Core Research for Evolutional Science and Technology

Awards: Basic study to explore molecular mechanism of the oocyte effecting on developmental potential, Dissecting the establishment and regulation of human pluripotency, Research for exploring totipotency of mouse zygotes, G5520316217, G7879866177

OpenAlex ID: W1513853071

Cites: 95

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Related to: 10