Is acetaminophen use associated with atopic eczema and other allergic diseases in adolescents?
Year: 2013
Type: article
Abstract: Atopic Eczema (AE) is a chronic inflammatory skin disease that affects children and adults, and alters quality of life. Previous studies have suggested several socio-demographic and environmental factors related to the prevalence of AE and other allergic diseases, including acetaminophen use. In the present study, we report the rates of isolated AE, AE associated with asthma and AE associated with rhinitis among 13- to 14-year-old Spanish adolescents and the level of association of these conditions with the use of acetaminophen. We analyzed Spanish data from a cross-sectional Phase 3 study within ISAAC. A total of 28,717 adolescents completed the Phase 3 written questionnaire by answering questions for acetaminophen use and on asthma, rhinitis and AE symptoms.We observed an association between acetaminophen use and AE among the adolescents who had used acetaminophen in the previous month. Furthermore, the prevalence rate increased with the number of allergic processes: for AE alone, the adjusted Prevalence Ratio (aPR) was 1.81 and for AE associated with rhinitis or with asthma, aPRs were 2.20 and 3.03, respectively.We conclude that acetaminophen use in childhood may be an important factor associated with development and/or maintenance of AE and other allergic diseases.
Source: PubMed
Authors: María Morales Suárez-Varela, Luís García-Marcos, Javier Fuertes Fernández-Espinar, Alberto Bercedo-Sanz, Inés Aguinaga-Ontoso, Carlos González-Díaz, Ignacio Carvajal-Urueña, Rosa María Busquet-Monge, Alberto Arnedo-Pena, Nagore García de Andoin, José Batlles-Garrido, Alfredo Blanco-Quirós, Angel López-Silvarrey Varela, Gloria García-Hernández, Natalia Gimeno-Clemente, Nuria Rubio-López, Agustín Llopis-González
Institutions: Universitat de València, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Universidad de Murcia, Hospital Perpetuo Socorro, Universidad Pública de Navarra (UPNA), Universidad de Navarra, Hospital de Basurto, Servicio de Salud del Principado de Asturias, Hospital Del Mar, Donostiako Unibertsitate Ospitalea, Complejo Hospitalario Torrecárdenas, Universidad de Valladolid, Fundación María José Jove
Language: English
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1514327294