Work

Effective clearance of mouse hepatitis virus from the central nervous system requires both CD4+ and CD8+ T cells

Year: 1990

Type: article

Abstract: Both CD4+ and CD8+ T cells are required for the clearance of virus from the central nervous system following infection with the JHM strain of mouse hepatitis virus. Development of antiviral antibodies requires the presence of CD4+ T cells but appears to play a minimal role in the reduction of virus. The data presented are consistent with the hypothesis that clearance of JHM virus is mediated by virus-specific CD8+ T cells, which appear to require the presence of CD4+ T cells.

Source: Journal of Virology

DOI: 10.1128/jvi.64.9.4589-4592.1990

Authors: J S Williamson, S A Stohlman

Institution: University of Southern California

Language: English

Topic: Animal Virus Infections Studies

Subfield: Animal Science and Zoology

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Neurological Disorders and Stroke