Autophagy, inflammation and neurodegenerative disease
Year: 2010
Type: review
Abstract: Autophagy is emerging as a central regulator of cellular health and disease and, in the central nervous system (CNS), this homeostatic process appears to influence synaptic growth and plasticity. Herein, we review the evidence that dysregulation of autophagy may contribute to several neurodegenerative diseases of the CNS. Up-regulation of autophagy may prevent, delay or ameliorate at least some of these disorders, and - based on recent findings from our laboratory - we speculate that this goal may be achieved using a safe, simple and inexpensive approach.
Source: European Journal of Neuroscience
Institution: Scripps Research Institute
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: ANALYSES OF CYTOTOXIC T CELL RESPONSE TO VIRUS INFECTION, Coxsackie Myocarditis and Viral Persistence in the Heart, G3382987919, Functional Analyses of Antiviral CD4+ T Cell Responses, Cytotoxic T Cell Responses to Virus Infection, G6711313182, Cytotoxic T Cell Responses to Virus Infection, Functional analyses of antiviral CD4+ T cell responses, G8461743331
OpenAlex ID: W1514528045