Year: 2011
Type: book-chapter
Abstract: Further review of full texts resulted in inclusion of 20 articles. Quality assessmentSystematic reviews need to assess the methodological quality of the included studies (Pai, et al., 2004).Quality within the context of this chapter refers to the minimization of bias.An objective of this assessment was to judge the strength of the scientific evidence with higher score given to studies free of bias.To minimize bias, the comparison group needs to be matched as close as possible to the DS group.In addition, the evaluated parameters should be assessed in the same manner between the groups.Studies with an adequately matched control group were scored higher than studies that used population data or previously collected data for comparison.The instrument used for judging articles for this chapter was based freely on the use of STROBE methodology (von Elm, et al., 2007) evaluating the following parameters: Down syndrome diagnosis: clearly stated and explained. Inclusion of a comparison group: well matched (age, gender, race) or not. Periodontal parameters: how periodontitis was defined and measured.Adequate if clinical attachment level was reported.Inadequate when only periodontal probing depth or radiographic measurements are reported. Laboratory methodology to assess microbial, immune or inflammatory factors: was the methodology clearly explained.Was the methodology appropriate or not. Examiner calibration: adequate if reported, inadequate if not reported. Descriptive information: characteristics of study participants (number of subjects, gender, mean and range of age) were clearly presented. Confounders identified: confounders that may affect periodontal status such as age, gender, and plaque levels were clearly defined. Data analysis: adequate when multivariate analysis adjusting for confounders was presented.Inadequate if only bivariate analysis was presented.The studies included in the review were scored as follows: Score 1: when all the parameters presented above were reported in the study. Score 2: when only DS diagnosis, inclusion of a comparison group, clinical periodontal measures and laboratory measures were reported. Score 3: other than score 1 and 2. How to referenceIn order to correctly reference this scholarly work, feel free to copy and paste the following:Ahmed Khocht (2011).Down Syndrome and Periodontal Disease, Genetics and Etiology of Down Syndrome, Prof.
Source: InTech eBooks
DOI: 10.5772/17371
Author: Ahmed Khocht
Institution: Temple University
Language: English
Subfield: Periodontics
Field: Dentistry
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W1515163996