Dopamine D1 and D2 receptor functional regulation: Glutamate Receptor Gene Expression in the Brain of Hypoglycaemic and Hyperglycaemic rats
Year: 2007
Type: dissertation
Abstract: In the present study a detailed investigation on the alterations of dopamine\nand its receptors in the brain regions of streptozotocin induced diabetic and insulin\ninduced hypoglycaemic rats were carried out. Glutamate receptor, NMDARI gene\nexpression in the hypoglycaemic and hyperglycaemic brain was also studied. EEG\nrecording in hypoglycaemic and hyperglycaemic will be carried out to measure brain\nactivity. in vitro studies on glucose uptake and insulin secretion, with and without\nspecific antagonists were carried out to confirm the specific receptor subtypes - DA\nD1, DA D2 and NMDA involved in the functional regulation during hyperglycaemic\nand hypoglycaemic brain damage. The molecular studies on the brain damage\nthrough dopaminergic and glutamergic receptors will elucidate the therapeutic role in\nthe corrective measures of the damage to the brain during hypoglycaemia and\nhyperglycaemia. This has importance in the management of diabetes and antidiabetic\ntreatment for better intellectual functioning of the individual.
Authors: Robinson Remya, C.S. Paulose
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1516623678