Matrix metalloproteinases in human wounds and epithelial cancer in the skin and oral mucosa
Year: 2004
Type: dissertation
Abstract: Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteolytic enzymes that are collectively able to degrade all components of the extracellular matrix (ECM).MMPs influence cell dissociation, death and division, angiogenesis, and the bioavailability of growth factors and cytokines, events needed in wound healing and tumor invasion.Normal cutaneous reepithelialization involves many MMPs, including MMP-1, -9, and -10 in migratory keratinocytes and MMP-3, -19 and -28 in the proliferating zone.However, many of these same MMPs as well as various others, such as MMPs-1, -2, -7, -9, -13, -14 and -26, have been implicated for various cancers.
Source: Työväentutkimus Vuosikirja
Author: Ulla Impola
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W1516825900