Observations related to pathogenesis of dengue hemorrhagic fever. IV. Relation of disease severity to antibody response and virus recovered.
Year: 1970
Type: article
Study design: Observational Study
Abstract: We have previously shown that disease differing widely in severity and prognosis is included in the entity, dengue hemorrhagic fever (DHF) in Thailand."2 Nearly 40 percent of 523 children hospitalized with DHF had a syndrome characterized by shock following a fever of several days duration. The rest had less severe febrile illnesses with various mild hemorrhagic manifestations. When sera from these children were studied, a significant correlation between shocked patients and a secondary-type antibody response to dengue virus was found.8 This report considers in greater detail the various manifestations of dengue disease and the antibody response in the host. Observations are included that suggest that severity of host response to dengue infection is influenced by an interaction between immune status and the age and sex of the patient. Associations between severity of illness and the rate of virus recovery, the quantity of antibody produced and the type of dengue virus recovered are described. A synthesis of these data and their relevance to the pathogenesis of human dengue infection are
Source: PubMed Central
Authors: S B Halstead, S Nimmannitya, S N Cohen
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1517364942