Influenza nucleoprotein-specific cytotoxic T-cell clones are protective in vivo.
Year: 1986
Type: article
Abstract: Influenza nucleoprotein (NP) serves as a target antigen on abortively infected cells for cytotoxic T cells (Tc) cross-reactive for all type A influenza viruses, and it can also prime mice for such Tc. It is important to test the protective ability of NP-specific Tc clones in vivo in a productive influenza infection. In this report, we show that Tc clones of this antigenic specificity protect mice against a lethal influenza infection on transfer to syngeneic recipients, and also that they reduce virus titres in the lungs and trachea of mice challenged with homologous or heterologous type A influenza viruses. Simultaneous injection of IL-2 to maintain the viability of the Tc clones is not essential, but has made the clonal transfer experiments highly reproducible.
Source: PubMed Central
Authors: P M Taylor, B A Askonas
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1517946762