Work

Krüppel-like factor 8 emerges as an important regulator of cancer.

Year: 2012

Type: article

Abstract: Krüppel-like factor 8 (KLF8) is a young member of the KLF transcription factor family proteins. It is highly overexpressed in several types of human cancers and regulates various cellular processes important for tumor progression. Increasing evidence has made KLF8 a new focus in cancer research and a potential target for cancer therapy. This review highlights the role of KLF8 in cancer by summarizing the up-to-date studies into its structure, function as a dual transcription factor, target genes and mechanisms of expression and modifications.

Source: Europe PMC (PubMed Central)

Authors: Satadru K Lahiri, Jihe Zhao

Language: English

Topic: Kruppel-like factors research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: University of Central Florida, National Cancer Institute

Award: KLF8 Regulation of EMT Tumor Metastasis

OpenAlex ID: W1518232925

FWCI: 2.573

Cites: 31

Cited by: 45

Related to: 10