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Rifampin-resistant replication of pBR322 derivatives in Escherichia coli cells induced for the SOS response

Year: 1991

Type: article

Abstract: Replication of plasmid pBR322 in Escherichia coli cells normally requires RNA synthesis and thus is sensitive to rifampin, an inhibitor of RNA polymerase. In cells induced for the SOS response, however, derivatives of pBR322 were found to replicate in the presence of rifampin. This rifampin-resistant replication of pBR322 requires the insertion of certain sequences of DNA. The replication depends on recF+ and DNA polymerase I.

Source: Journal of Bacteriology

DOI: 10.1128/jb.173.15.4736-4741.1991

Authors: T R Magee, T Kogoma

Institution: University of New Mexico

Language: English

Topic: Bacterial Genetics and Biotechnology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of General Medical Sciences, Fogarty International Center