Year: 2011
Type: book-chapter
Abstract: NKG2D2.1 Molecular structure and expression NKG2D is a type II transmembering glycoprotein, containing C-type lectin-like domains, similar to other known NKG2 family (Eagle and Trowsdale, 2007).Although physically clustered with other NKG2 family members, NKG2D only displays 20-30% sequence homology with other members of the NKG2 family.NKG2D is highly conserved between species.For instance, human NKG2D and mouse NKG2D share 70% amino acid identity (Raulet, 2003).NKG2D was originally identified as a key activating receptor of NK cells.Subsequently NKG2D is identified on all human CD8 T cells, NKT cells, subsets of γδ T cells.In murine, NKG2D was expressed by activated and memory CD8 T cells, a proportion (25%) of splenic γδ T cells, and activated macrophages (Diefenbach et al., 2000;Mistry and O'Callaghan, 2007).Precancerous normal ma lignant Tumor NK cell NK, T cell NK, T c ell no activation Activation Anti-tumor immunity NKG2D MIC NKG2 D Impairment Tumor evasion and progression How to referenceIn order to correctly reference this scholarly work, feel free to copy and paste the following:
Source: InTech eBooks
DOI: 10.5772/23523
Authors: Jennifer Wu, Xuanjun Wang
Institutions: University of Washington, Yunnan Agricultural University
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W1519073835