Year: 2015
Type: article
Study design: Observational Study
Abstract: The role of amount and type of dietary fat consumption in the etiology of hepatocellular carcinoma (HCC) is poorly understood, despite suggestive biological plausibility. The associations of total fat, fat subtypes and fat sources with HCC incidence were investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, which includes 191 incident HCC cases diagnosed between 1992 and 2010. Diet was assessed by country-specific, validated dietary questionnaires. A single 24-hr diet recall from a cohort subsample was used for measurement error calibration. Hazard ratios (HR) and 95% confidence intervals (95% CI) were estimated from Cox proportional hazard models. Hepatitis B and C viruses (HBV/HCV) status and biomarkers of liver function were assessed separately in a nested case-control subset with available blood samples (HCC = 122). In multivariable calibrated models, there was a statistically significant inverse association between total fat intake and risk of HCC (per 10 g/day, HR = 0.80, 95% CI: 0.65-0.99), which was mainly driven by monounsaturated fats (per 5 g/day, HR = 0.71, 95% CI: 0.55-0.92) rather than polyunsaturated fats (per 5 g/day, HR = 0.92, 95% CI: 0.68-1.25). There was no association between saturated fats (HR = 1.08, 95% CI: 0.88-1.34) and HCC risk. The ratio of polyunsaturated/monounsaturated fats to saturated fats was not significantly associated with HCC risk (per 0.2 point, HR = 0.86, 95% CI: 0.73-1.01). Restriction of analyses to HBV/HCV free participants or adjustment for liver function did not substantially alter the findings. In this large prospective European cohort, higher consumption of monounsaturated fats is associated with lower HCC risk.
Source: International Journal of Cancer
DOI: 10.1002/ijc.29643
Authors: Talita Duarte‐Salles, Veronika Fedirko, Magdalena Stepien, Krasimira Aleksandrova, Christina Bamia, Pagona Lagiou, Anne Sofie Dam Laursen, Louise Hansen, Kim Overvad, Anne Tjønneland, Marie‐Christine Boutron‐Ruault, Guy Fagherazzi, Mathilde His, Heiner Boeing, Verena Katzke, Tilman Kühn, Antonia Trichopoulou, Elissavet Valanou, Maria Kritikou, Giovanna Masala, Salvatore Panico, Sabina Sieri, Fulvio Ricceri, Rosario Tumino, H. B(as) Bueno‐de‐Mesquita, Petra H. Peeters, Anette Hjartåker, Guri Skeie, Elisabete Weiderpass, Eva Ardanaz, Catalina Bonet, Maria‐Dolores Chirlaque, Miren Dorronsoro, J. Ramón Quirós, Ingegerd Johansson, Bodil Ohlsson, Klas Sjöberg, Maria Wennberg, Kay‐Tee Khaw, Ruth C. Travis, Nick Wareham, Pietro Ferrari, Heinz Freisling, Isabelle Romieu, Amanda J. Cross, Marc Gunter, Yunxia Lu, Mazda Jenab
Institutions: Centre international de recherche sur le cancer, Emory University, Winship Cancer Institute, German Institute of Human Nutrition, National and Kapodistrian University of Athens, Harvard University, Academy of Athens, Aarhus University, Danish Cancer Society, Inserm, Institut Gustave Roussy, Centre de recherche en Epidémiologie et Santé des Populations, German Cancer Research Center, Hellenic Health Foundation, Istituto per lo Studio e la Prevenzione Oncologica, Federico II University Hospital, University of Naples Federico II, Fondazione IRCCS Istituto Nazionale dei Tumori, Piedmont Reference Center for Epidemiology and Cancer Prevention, University of Turin, Azienda Usl 8 Arezzo, University Medical Center Utrecht, University of Malaya, National Institute for Public Health and the Environment, Imperial College London, University of Oslo, UiT The Arctic University of Norway, Karolinska Institutet, Cancer Registry of Norway, Folkhälsans Forskningscentrum, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Institut Català d'Oncologia, Instituto Murciano de Investigación Biosanitaria, Biogipuzkoa Health Research Institute, Gobierno del Principado de Asturias, Umeå University, Lund University, Skåne University Hospital, University of Cambridge, University of Oxford, MRC Epidemiology Unit
Language: English
Topic: Nutritional Studies and Diet
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: World Health Organization, Deutsches Krebsforschungszentrum, Wellcome Trust, Cancer Research UK, National Institute for Health and Care Research, British Heart Foundation, European Commission, Institut National de la Santé et de la Recherche Médicale, Bundesministerium für Bildung und Forschung, Cancerfonden, Ministerie van Volksgezondheid, Welzijn en Sport, Ligue Contre le Cancer, Associazione Italiana per la Ricerca sul Cancro, Deutsche Krebshilfe, Institut National Du Cancer, Institut Gustave-Roussy, Mutuelle Générale de l'Education Nationale, Hellenic Health Foundation, Abbott Diagnostics, Medical Research Council, World Cancer Research Fund, Instituto de Salud Carlos III, Health and Medical Research Fund, National Cancer Institute
Awards: G1090603134, G1241080153, G1952936224, G2064004790, G240156421, G3170664214, G3461390129, G3816092139, G4015156572, G423622538, G4885864782, G5047213743, G5897142711, NIHR Senior Investigator Award, G640002926, G6457389867, G6723261869, G6957823285, G7022277044, G8012318887, G8129616127, NIHR Senior Investigator Award, G876765158
OpenAlex ID: W1520005158