Work

Strategies for the synthesis of the novel antitumor agent peloruside A.

Year: 2008

Type: review

Abstract: The microtubule-stabilizing agent (+)-peloruside A has emerged as a potential therapeutic agent for the treatment of cancer. Two total syntheses have been published and these reports have stimulated additional studies to advance the methodology and strategies for accessing this molecular architecture. This review details the biological data, modeling and conformation analyses, and synthetic studies toward the synthesis of (+)-peloruside A, that were reported prior to December 2007.

Source: PubMed

Authors: David R Williams, Partha P Nag, Nicolas Zorn

Institutions: Indiana University Bloomington, Indiana University

Language: English

Topic: Biological Activity of Diterpenoids and Biflavonoids

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of General Medical Sciences

Award: Chemical Synthesis of Novel Natural Products