Work

Corpus Callosum Shape and Size Changes in Early Alzheimer's Disease: A Longitudinal MRI Study Using the OASIS Brain Database

Year: 2014

Type: article

Abstract: BACKGROUND: Alzheimer's disease (AD) has been shown to be associated with shrinkage of the corpus callosum mid-sagittal cross-sectional area (CCA). OBJECTIVE: To study temporal rates of corpus callosum atrophy not previously reported for early AD. METHODS: We used longitudinal MRI scans to study the rates of change of CCA and circularity (CIR), a measure of its shape, in normal controls (NC, n = 75), patients with very mild AD (AD-VM, n = 51), and mild AD (AD-M, n = 21). RESULTS: There were significant reduction rates in CCA and CIR in all three groups. While CCA reduction rates were not statistically different between groups, the CIR declined faster in AD-VM (p < 0.03) and AD-M (p < 0.0001) relative to NC, and in AD-M relative to AD-VM (p < 0.0004). CONCLUSION: CIR declines at an accelerated rate with AD severity. Its rate of change is more closely associated with AD progression than CCA or any of its sub-regions. CIR may be a useful group biomarker for objective assessment of treatments that aim to slow AD progression.

Source: Journal of Alzheimer s Disease

DOI: 10.3233/jad-131526

Authors: Alvin H. Bachman, Sang Han Lee, John J. Sidtis, Babak A. Ardekani

Institutions: Nathan Kline Institute for Psychiatric Research, NYU Langone Health, New York University

Language: English

Topic: Dementia and Cognitive Impairment Research

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute on Aging, National Institute of Mental Health, National Institute on Deafness and Other Communication Disorders, National Center for Research Resources