An Exonuclease Induced by Bacteriophage λ
Year: 1967
Type: article
Abstract: λ exonuclease exhibits a much greater rate of attack on native deoxyribonucleic acid than on denatured DNA, the difference in rate being 350-fold for T7 phage DNA. The attack is exclusively exonucleolytic, and the only acid-soluble products are deoxyribonucleoside 5‘-monophosphates. In contrast to the known Escherichia coli exonucleases, its initial site of attack is at the 5‘ termini of a DNA molecule, with a strong preference for termini bearing a phosphoryl residue as compared with those bearing a free hydroxyl group.
Source: Journal of Biological Chemistry
Author: John W. Little
Institutions: Stanford Medicine, Stanford University
Language: English
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,430
OpenAlex ID: W1520987654