Work

A reversal of Glagov's hypothesis; a preliminary demonstration by cardiac magnetic resonance

Year: 2011

Type: article

Abstract: According to Glagov's hypothesis, the early stages of atherogenesis (stenosis <40%) are associated with positive remodeling of the outer arterial wall resulting in paradoxical preservation of the luminal area, and as stenosis exceeds 40%, further plaque accumulation results in a decrease in the area of the lumen. This study examines the effects of statins on human carotid atherosclerotic plaque to investigate if a reversal of Glagov's hypothesis occurs with statin therapy.

Source: Journal of Cardiovascular Magnetic Resonance

DOI: 10.1186/1532-429x-13-s1-p178