Coffee and tea consumption, genotype-basedCYP1A2andNAT2activity and colorectal cancer risk-Results from the EPIC cohort study
Year: 2013
Type: article
Study design: Observational Study
Abstract: Coffee and tea contain numerous antimutagenic and antioxidant components and high levels of caffeine that may protect against colorectal cancer (CRC). We investigated the association between coffee and tea consumption and CRC risk and studied potential effect modification by CYP1A2 and NAT2 genotypes, enzymes involved in the metabolization of caffeine. Data from 477,071 participants (70.2% female) of the European Investigation into Cancer and Nutrition (EPIC) cohort study were analyzed. At baseline (1992-2000) habitual (total, caffeinated and decaffeinated) coffee and tea consumption was assessed with dietary questionnaires. Cox proportional hazards models were used to estimate adjusted hazard ratio's (HR) and 95% confidence intervals (95% CI). Potential effect modification by genotype-based CYP1A2 and NAT2 activity was studied in a nested case-control set of 1,252 cases and 2,175 controls. After a median follow-up of 11.6 years, 4,234 participants developed CRC (mean age 64.7 ± 8.3 years). Total coffee consumption (high vs. non/low) was not associated with CRC risk (HR 1.06, 95% CI 0.95-1.18) or subsite cancers, and no significant associations were found for caffeinated (HR 1.10, 95% CI 0.97-1.26) and decaffeinated coffee (HR 0.96, 95% CI 0.84-1.11) and tea (HR 0.97, 95% CI 0.86-1.09). High coffee and tea consuming subjects with slow CYP1A2 or NAT2 activity had a similar CRC risk compared to non/low coffee and tea consuming subjects with a fast CYP1A2 or NAT2 activity, which suggests that caffeine metabolism does not affect the link between coffee and tea consumption and CRC risk. This study shows that coffee and tea consumption is not likely to be associated with overall CRC.
Source: International Journal of Cancer
DOI: 10.1002/ijc.28655
Authors: Vincent K. Dik, H. Bas Bueno-de-Mesquita, Martijn G.H. Van Oijen, Peter D. Siersema, Cuno S.P.M. Uiterwaal, Carla H. Van Gils, Fränzel J.B. Van Duijnhoven, Stéphane Cauchi, Loic Yengo, Philippe Froguel, Kim Overvad, Bodil H. Bech, Anne Tjønneland, Anja Olsen, Marie-Christine Boutron-Ruault, Antoine Racine, Guy Fagherazzi, Tilman Kühn, Daniele Campa, Heiner Boeing, Krasimira Aleksandrova, Antonia Trichopoulou, Eleni Peppa, Eleni Oikonomou, Domenico Palli, Sara Grioni, Paolo Vineis, Rosaria Tumino, Salvatore Panico, Petra H.M. Peeters, Elisabete Weiderpass, Dagrun Engeset, Tonje Braaten, Miren Dorronsoro, María-Dolores Chirlaque, María-José Sánchez, Aurelio Barricarte, Raul Zamora-Ros, Marcial Argüelles, Karin Jirström, Peter Wallström, Lena M. Nilsson, Ingrid Ljuslinder, Ruth C. Travis, Kay-Tee Khaw, Nick Wareham, Heinz Freisling, Idlir Licaj, Mazda Jenab, Marc J. Gunter, Neil Murphy, Dora Romaguera-Bosch, Elio Riboli
Institutions: University Medical Center Utrecht, National Institute for Public Health and the Environment, Imperial College London, Wageningen University & Research, Centre National de la Recherche Scientifique, Université de Lille, Institut Pasteur de Lille, European Genomic Institute for Diabetes, Aarhus University, Danish Cancer Society, Université Paris-Sud, Inserm, Institut Gustave Roussy, Centre de recherche en Epidémiologie et Santé des Populations, German Cancer Research Center, German Institute of Human Nutrition, Hellenic Health Foundation, National and Kapodistrian University of Athens, Istituto per lo Studio e la Prevenzione Oncologica, Fondazione IRCCS Istituto Nazionale dei Tumori, Italian institute for Genomic Medicine, Azienda Usl 8 Arezzo, Federico II University Hospital, University of Naples Federico II, Karolinska Institutet, Cancer Registry of Norway, Folkhälsans Forskningscentrum, UiT The Arctic University of Norway, Biogipuzkoa Health Research Institute, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Comunidad Autónoma de la Región de Murcia, Instituto de Investigación Biosanitaria de Granada, Andalusian School of Public Health, Institut Català d'Oncologia, Gobierno del Principado de Asturias, Lund University, Skåne University Hospital, Arctic Research Centre, Umeå University, University of Oxford, University of Cambridge, Addenbrooke's Hospital, MRC Epidemiology Unit, Medical Research Council, Centre international de recherche sur le cancer, Centro de Investigación Biomédica en Red
Language: English
Topic: Coffee research and impacts
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1522160328