Combining information from multiple sources for the diagnosis of autism spectrum disorders for toddlers and young preschoolers from 12 to 47 months of age
Year: 2011
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Purpose of this study was to systematically examine combined use of the Autism Diagnostic Interview-Revised (ADI-R) and Autism Diagnostic Observation Schedule (ADOS) for children under age 4 using newly developed and revised diagnostic algorithms. METHODS: Single and combined use of the ADI-R and ADOS algorithms were compared to clinical best estimate diagnoses for 435 children with autism spectrum disorders (ASD), 113 children with nonspectrum disorders, and 47 children with typical development from 12 to 47 months of age. Sequential strategies to reach a diagnostic decision by prioritizing administrations of instruments were also evaluated. RESULTS: Well-balanced sensitivities and specificities above 80% were obtained for ASD diagnoses using both instruments. Specificities significantly improved when both instruments were used compared to one. Scores that can be used to systematically prioritize administrations of instruments were identified. CONCLUSIONS: The ADI-R and ADOS make independent, additive contributions to more accurate diagnostic decisions for clinicians evaluating toddlers and young preschoolers with ASD. Sequential assessment strategies using the scores identified may be appropriate for some children.
Authors: So Hyun Kim, Catherine Lord
Institution: University of Michigan
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
Awards: Validity of Diagnostic Measures for Autistic Spectrum, G1616642145, Neurobiology and genetics of Autism & Related Conditions, TRAINING IN DIAGNOSIS OF AUTISM SPECTRUM DISORDERS, AMPA receptors plasticity regulated by stargazin, G5009579607, NEUROBIOLOGY AND GENETICS OF AUTISM/RELATED CONDITIONS, G7440403863
OpenAlex ID: W1522674123