Efecto protector de la Spirulina platensis sobre el hígado graso inducido con tetracloruro de carbono, a una dosis subletal, en ratas Wistar
Year: 2014
Type: article
Abstract: It has been reported that Spirulina maxima and other natural products are effective in attenuating hepatic damage. In this study were analyzed the effects of five days dietary Spirulina platensis (5%) in rats with fatty liver induced by CCl4 (2 mL/kg b.w.). Animals were sacrificed at 24 and 48 h post-treatment. In the liver were evaluated total lipids by gravimetry and lipid profile by enzymatic-colorimetric methods, the concentration of thiobarbituric acid reactive substances and nitric oxide by chemical methods. In serum, alanine aminotransferase (kinetic method) and lipid profile were evaluated. The most important effects on the liver were: attenuation in lipid peroxidation, minimal variations on the total fatty acid methyl esters profile, and nitric oxide. These results suggest that Spirulina platensis could be used for fatty liver treatment as an alimentary supplement.
Language: English
Subfield: Pharmacology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W1522753169