Work

Redundant kinase activation and resistance of EGFR-tyrosine kinase inhibitors.

Year: 2014

Type: article

Abstract: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have shown dramatic effects against that tumors harboring EGFR activating mutations in the EGFR intracytoplasmic tyrosine kinase domain and resulted in cell apoptosis. Unfortunately, a number of patients ultimately developed resistance by multiple mechanisms. Thus, elucidation of the mechanism of resistance to EGFR-TKIs can provide strategies for blocking or reversing the situation. Recent studies suggested that redundant kinase activation plays pivotal roles in escaping from the effects of EGFR-TKIs. Herein, we aimed to characterize several molecular events involved in the resistance to EGFR-TKIs mediated by redundant kinase activation.

Source: Europe PMC (PubMed Central)

Authors: Min Luo, Li-Wu Fu

Institutions: Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China

Language: English

Topic: Lung Cancer Treatments and Mutations

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W152279435

FWCI: 3.441

Cites: 160

Cited by: 38

Related to: 10