Year: 2003
Type: book-chapter
Abstract: Genetic analysis aims to determine which underlying genes affect traits, their chromosomal locations and variants, and, ultimately, their modes of action at the biochemical level.Linkage analysis is an initial step in elucidating the genetic mechanisms affecting a trait of interest.This paper reviews genetic linkage analysis, with an emphasis on the score test approach developed by Dudoit and Speed [8,10].Two extensions of the test under current investigation are also presented: use of the test with larger sets of relatives than pairs, and generalization to allow for missing DNA identity by descent (IBD) information.
Source: Lecture notes-monograph series
Authors: Sandrine Dudoit, Darlene R. Goldstein
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W1523542393