Work

Mouse Models of Human Bladder Cancer as a Tool for Drug Discovery

Year: 2010

Type: article

Abstract: Muscle-invasive bladder cancer is a deadly condition in dire need of effective new treatments. This unit contains a description of mouse models suitable for the evaluation of potential new therapies. Included is a genetically engineered mouse model of bladder cancer generated by the delivery of an adenovirus expressing Cre recombinase into the bladder lumen. Also described is an orthotopic mouse model created by the instillation of human bladder tumor cells into the bladder lumen of immune deficient mice. Protocols are also provided on the use of these models for the preclinical evaluation of new chemical entities, with mTOR inhibitors shown as an example.

Source: Current Protocols in Pharmacology

DOI: 10.1002/0471141755.ph1414s49

Authors: Catherine Seager, Anna M. Puzio‐Kuter, Carlos Cordon‐Cardo, James McKiernan, Cory Abate‐Shen

Institutions: Columbia University Irving Medical Center, Herbert Irving Comprehensive Cancer Center

Language: English

Topic: Bladder and Urothelial Cancer Treatments

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: American Cancer Society, Alexander and Margaret Stewart Trust, National Cancer Institute