Work

Cell-Trappable Fluorescent Probes for Nitric Oxide Visualization in Living Cells

Year: 2010

Type: article

Abstract: Two new cell-trappable fluorescent probes for nitric oxide (NO) are reported based on either incorporation of hydrolyzable esters or conjugation to aminodextran polymers. Both probes are highly selective for NO over other reactive oxygen and nitrogen species (RONS). The efficacy of these probes for the fluorescence imaging of nitric oxide produced endogenously in Raw 264.7 cells is demonstrated.

Source: Organic Letters

DOI: 10.1021/ol1006289

Authors: Michael D. Pluth, Lindsey E. McQuade, Stephen J. Lippard

Institution: Massachusetts Institute of Technology

Language: English

Topic: Molecular Sensors and Ion Detection

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Science Foundation, National Institutes of Health, National Institute of General Medical Sciences, Division of Chemistry

Award: Fluorescence Sensing of NO: Development of Reversible Sensors Using Fe(III)