Work

Polycystic Ovary Induction in Mouse by Testosterone Enanthate

Year: 2014

Type: article

Abstract: Background &Objective: Polycystic ovary is the most common cause of infertility in Women. Animal models are required for understanding the pathogenesis of polycystic ovary. The objective of this study then was to develop an animal model for inducing the polycystic ovaries using testosterone enanthate.Materials & Methods: In this study, for inducing the polycystic ovary phenotype, female rats about12-14 days-old were injected daily with testosterone enanthate for 2 and 4 weeks (experiment groups: 1 and 2), while the control groups (1 and 2) were injected only with vehicle.The ovaries from both groups were fixed and then were used for histological studies.Results: Testosterone enanthate treatment causes the histological changes in mouse ovary and significantly increased the percentage of preantral and cystic follicles and decreased the percentage of antral follicles in the experiment group, comparing with the control group (P<0.05).Conclusion: It concluded that testosterone enanthate can induces polycystic ovary in mouse.

Source: DOAJ (DOAJ: Directory of Open Access Journals)

Authors: Zahra Kalhori, Mehri Azadbakht, Ali Bazdar, H Zeinali

Institution: Razi University

Language: English

Topic: Ovarian function and disorders

Subfield: Reproductive Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W1526576662

FWCI: 0.811

Cites: 13

Cited by: 6

Related to: 10