Work

A Compartmental Lateral Inhibition System to Generate Contrasting Patterns

Year: 2015

Type: article

Abstract: We propose a lateral inhibition system and analyze contrasting patterns of gene expression. The system consists of a set of compartments interconnected by channels. Each compartment contains a colony of cells that produce diffusible molecules to be detected by the neighboring colonies. Each cell is equipped with an inhibitory circuit that reduces its production when the detected signal is sufficiently strong. We characterize the parameter range in which steady-state patterns emerge.

Source: IEEE Life Sciences Letters

DOI: 10.1109/lls.2015.2446211

Authors: Ana Sofia Rufino Ferreira, Justin Hsia, Murat Arcak

Institution: University of California, Berkeley

Language: English

Topic: Gene Regulatory Network Analysis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Award: Mathematics and Synthesis of a Contact-Mediated Multicellular Patterning System