Efeito da Administração Oral de Precursores Gliconeogênicos Hepáticos na Recuperação da Hipoglicemia Induzida por Insulina (HII)
Year: 2011
Type: article
Abstract: Although intensive insulin therapy determines a strict glycaemic control, an increased incidence of insulin-induced hypoglycemia (IIH) occurs. The availability of gluconeogenic precursors is crucial for hepatic glucose production and oral supply promotes differentiated recovery of blood glucose. Since the liver plays a central role in the regulation of blood glucose, current research investigates its involvement in the mechanisms of IIH recovery by the oral administration of gluconeogenic precursors in rats fasting for 6 hours. Results show that glycerol, pyruvic acid and L-glutamine tended towards a rise in blood glucose levels 8 min after gavage. However, after 30 min, only L-alanine and L-glutamine showed the lowest decrease in blood glucose. Pyruvic acid and glycerol showed the same transient glucose effect on the recovery of blood glucose, or rather, an initial rise and subsequent worsening of the condition. After one hour the positive effect of L-alanine disappeared and became inappropriate for a decrease in blood glucose during prolonged periods, while L-glutamine maintained a higher glycaemic rate. Perhaps due to the fact that the hepatocyte is reduced when L-glutamine is the gluconeogenic precursor, the effect of this aminoacid would in the long run be favored.
Source: Saúde e Pesquisa
Authors: Garcia, Rosângela Fernandes, Moreno, Franciele Neves, Nascimento, Kátia Fialho do, Gazola, Vilma Ferreira
Institution: Universidade Estadual de Maringá
Language: Portuguese
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W1527583898