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Association of GATA4 sequence variation with alcohol dependence

Year: 2012
Type: article
Study design: Observational Study
Abstract: To further explore reports of association of alcohol dependence and response to acamprosate treatment with the GATA4 rs13273672 single nucleotide polymorphism (SNP), we genotyped this and 10 other GATA4 SNPs in 816 alcohol-dependent cases and 1248 controls. We tested for association of alcohol dependence with the 11 SNPs individually and performed a global test for association using a principle components analysis. Our analyses demonstrate significant association between GATA4 and alcohol dependence at the gene level (P = 0.009) but no association with rs13273672. Further studies are needed to identify potential causal GATA4 variation(s) and the functional mechanism(s) contributing to this association.
DOI: 10.1111/j.1369-1600.2012.00482.x
Authors: Victor M. Karpyak, Stacey J. Winham, Joanna M. Biernacka, Julie M. Cunningham, Kriste A. Lewis, Jennifer R. Geske, Colin L. Colby, Osama A. Abulseoud, Daniel K. Hall‐Flavin, Larissa L. Loukianova, Terry D. Schneekloth, Mark A. Frye, John A. Heit, David A. Mrazek
Institution: Mayo Clinic
Language: English
Subfield: Genetics
Open Access status: green
Funders: Mayo Clinic, Georgia Clinical and Translational Science Alliance, National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, National Human Genome Research Institute, National Cancer Institute, National Center for Research Resources, National Center for Advancing Translational Sciences
Awards: GWAS of Venous Thrombosis, G3860363877, G4780415273, The Mayo Clinic Center for Individualized Treatment of Alcohol Dependence, G8650166251, Mayo Clinic Center for Translational Science Activities, Mayo Clinic Comprehensive Cancer Center Support Grant
OpenAlex ID: W1527689088
FWCI: 1.147
Cites: 15
Cited by: 22
Related to: 10