Work

Exercise and Insulin

Year: 2009

Type: article

Abstract: In Brief Akt substrate of 160 kDa (called AS160 or TBC1D4) and TBC1D1, Rab GTPase-activating proteins that regulate glucose transport, become phosphorylated with exercise or insulin stimulation. Evidence suggests that this convergence may prove to be imperfect, and each stimulus will produce a unique phosphosignature, providing a plausible mechanism for their apparently unique and overlapping roles in exercise- and insulin-stimulated glucose transport. AS160 and TBC1D1, with overlapping and unique responses to insulin and exercise, seem to play distinct roles in glucose transport.

Source: Exercise and Sport Sciences Reviews

DOI: 10.1097/jes.0b013e3181b7b7c5

Authors: Gregory D. Cartee, Katsuhiko Funai

Institution: University of Michigan

Language: English

Topic: Metabolism, Diabetes, and Cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute on Aging, National Institute of Diabetes and Digestive and Kidney Diseases