Predominance of Right Hemisphere in Post-ischemic Stroke Immunity Modulation
Year: 2010
Type: article
Study design: Observational Study
Abstract: Post-ischaemic stroke infectious complications are commonly found. However, the post-stroke reduction of immunity modulation has never been clearly disclosed. This study, which was aimed to disclose immunomodulation mechanism of post-ischaemic stroke, was undertaken using cross-sectional observational method to patients aged 50-60 years with ischaemic stroke in left and right cerebral hemispheres, who were compared with healthy individuals. Analysis unit was blood from cubital veins taken 7 days after the first stroke attack. Immunity status observation was carried out by measuring total lymphocytes, monocytes, IL-10, IFN-γ, and TNF-β1. The analysis of immunity status in those three groups was done using multivariate approach. Results of Manova analysis revealed that immunity status in those groups had significant difference (Wilk’s Lambda, p < 0.05). Furthermore, discriminant analysis performed to obtain variable that had predominant contribution to immune response revealed the following results: (1) in group with ischaemic stroke in right hemisphere, a number of discriminant variable were monocytes, IL-10, IFN-γ, and TNF-β1, (2) in group with ischaemic stroke in left hemisphere, the discriminant variable were monocytes and IFN-γ. In conclusion, (1) ischaemic stroke, either in left and right hemispheres, induces different immunity modulation, (2) ischaemic stroke modulation in right hemisphere is contributed particularly by the role of monocytes IL-10, IFN-γ, and TNF-β1, while that in left hemisphere by only the role of monocytes and IFN-γ. The role of IFN-γ, IL-10 on the cell immunocompetence (monocyte) is psychoneuroimmunological approach. Based on those findings, it can be seen that the function of left hemisphere may be more predominant in complementary mechanism to maintain immunological defense of the body.
Source: Folia Medica Indonesiana
Author: Noer Rachma
Language: English
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $98
OpenAlex ID: W1528992832