Work

A novel fibronectin receptor with an unexpected subunit composition (alpha v beta 1).

Year: 1990

Type: article

Abstract: The integrins are a family of heterodimeric cell surface receptors for extracellular matrix molecules. An analysis of integrin subunits expressed by a number of cell lines identified a novel heterodimer. The alpha subunit of this integrin was immunologically and electrophoretically indistinguishable from the vitronectin receptor alpha subunit (alpha v) and the beta subunit was indistinguishable from beta 1. Affinity chromatography experiments and cell adhesion assays indicated that this receptor complex is a new fibronectin receptor. Its unexpected subunit composition demonstrates the importance of the beta subunit in determining the ligand specificity of integrins and suggests that the current integrin classification scheme needs revision.

Source: Journal of Biological Chemistry

DOI: 10.1016/s0021-9258(19)39268-3

Authors: B E Vogel, G Tarone, F G Giancotti, J Gailit, E Ruoslahti

Institution: Sanford Burnham Prebys Medical Discovery Institute

Language: English

Topic: Cell Adhesion Molecules Research

Subfield: Immunology and Allergy

Field: Medicine

Domain: Health Sciences

Open Access status: hybrid

Estimated APC paid: $3,430

Funders: National Institutes of Health, National Cancer Institute