Normotensive pheochromocytoma. Pharmacologic, paraneoplastic and anesthetic considerations.
Year: 1983
Type: article
Study design: Case Report
Abstract: ALTHOUGH HYPERTENSION, sustained or paroxysmal, is usually a cardinal feature of pheochromocytoma, cases in which patients with this disorder were normotensive have been reported.'-6To extend further the clinical spectrum associated with this tumor, we describe a normotensive patient in whom fever of unknown origin, anemia, thrombocytosis, abnormalities of hepatic func- tion and pronounced elevation of the erythrocyte sedi- mentation rate were the presenting features of a norepinephrine-and dopamine-secreting pheochromocytoma.Complete resolution of the fever and of the hematologic and biochemical abnormalities followed removal of this benign neoplasm. Report of a CaseA 22-year-old black man presented to San Francisco General Hospital Medical Center on May 3, 1976, with a 13-month history of an 18-kg (40-lb) weight loss, fatigue, palpitations, night sweats, chest pain, epigastric discomfort and postexertional emesis.In the two weeks before admission, fever had developed.The family medical history was unremarkable.Medical evaluation for the same symptoms seven and nine months before admission was remarkable for anemia, elevation of serum alkaline phosphatase level, reversal of albumin-globulin ratio and extreme eleva- tion of erythrocyte sedimentation rate (Table1) .Serum protein electrophoresis showed a diffuse increase in gamma globulin values.A bone marrow biopsy speci- men showed a reactive erythroid series with features typical of hemoglobin AC hemoglobinopathy and a reactive myeloid series indicating a chronic inflamma- tory state.Histologic examination of a liver biopsy specimen was interpreted as showing prominent dilated and congested central venous channels that suggested
Source: PubMed Central
Authors: B D Kirby, J Ham, H B Fairley, N Benowitz, M Schambelan
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
Award: G9000285476
OpenAlex ID: W1530136848