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Reexamination of the Morphogenetic Block of a Putative Late-Stage, Temperature-Sensitive Mutant of Moloney Murine Leukemia Virus

Year: 1983

Type: article

Abstract: The ts3 temperature-sensitive mutant of Moloney murine leukemia virus has been reported to have a morphogenetic block in a late stage of the budding process. As evidence, previously published electron micrographs of cells maintained at the nonpermissive temperature (39 degrees C) revealed numerous budding virions on the cell surface. However, it appears now that these micrographs reflected budding that occurred not at 39 degrees C, but after cells were removed from the incubator before fixation. The morphogenesis of ts3 is actually blocked at an earlier stage of development.

Source: Journal of Virology

DOI: 10.1128/jvi.45.3.1140-1142.1983

Authors: Anthony Demsey, Robert M. Friedman

Institutions: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Uniformed Services University of the Health Sciences

Language: English

Topic: T-cell and Retrovirus Studies

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: bronze

OpenAlex ID: W1530186683

FWCI:

Cites: 12

Cited by: 2

Related to: 10