Work

Transcription Blockage Leads to New Beginnings

Year: 2015

Type: review

Abstract: Environmental agents are constantly challenging cells by damaging DNA, leading to the blockage of transcription elongation. How do cells deal with transcription-blockage and how is transcription restarted after the blocking lesions are removed? Here we review the processes responsible for the removal of transcription-blocking lesions, as well as mechanisms of transcription restart. We also discuss recent data suggesting that blocked RNA polymerases may not resume transcription from the site of the lesion following its removal but, rather, are forced to start over from the beginning of genes.

Source: Biomolecules

DOI: 10.3390/biom5031600

Authors: Leonardo Andrade-Lima, Artur Veloso, Mats Ljungman

Institutions: Universidade de São Paulo, University of Michigan, Michigan Medicine

Language: English

Topic: DNA Repair Mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $3,258