Work

Emerging function of mTORC2 as a core regulator in glioblastoma: metabolic reprogramming and drug resistance.

Year: 2014

Type: article

Abstract: Glioblastoma (GBM) is one of the most lethal human cancers. Genomic analyses define the molecular architecture of GBM and highlight a central function for mechanistic target of rapamycin (mTOR) signaling. mTOR kinase exists in two multi-protein complexes, namely, mTORC1 and mTORC2. These complexes differ in terms of function, regulation and rapamycin sensitivity. mTORC1 is well established as a cancer drug target, whereas the functions of mTORC2 in cancer, including GBM, remains poorly understood. This study reviews the recent findings that demonstrate a central function of mTORC2 in regulating tumor growth, metabolic reprogramming, and targeted therapy resistance in GBM, which makes mTORC2 as a critical GBM drug target.

Source: PubMed

DOI: 10.7497/j.issn.2095-3941.2014.04.004

Authors: Si-Han Wu, Jun-Feng Bi, Timothy Cloughesy, Webster K Cavenee, Paul S Mischel

Institutions: University of California, Los Angeles, University of California San Diego

Language: English

Topic: PI3K/AKT/mTOR signaling in cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Cancer Institute, National Institute of Neurological Disorders and Stroke