Year: 2013
Type: book-chapter
Abstract: Glioblastoma multiforme (GBM) is the most common primary brain tumors and remains one of the deadliest of human cancers [1]. The incidence of this cancer is fairly low, with 2-3 cases per 100,000 people in Europe and North America. GBM is slightly more common in whites than in blacks, Latinos, and Asians, with a slight male predominance M:F ratio of 3:2 [2]. The overall prognosis for GBM has changed little in the past two decades, despite major improvements in neuroimaging, neurosurgery, radiation treatment techniques, adjuvant chemotherapy, and supportive care. Without treatment, the median survival is approximately 3 months [3]. The current standard of care involves maximal surgical resection followed by concurrent radiation and chemotherapy with the DNA alkylating agent temozolomide [4]. Despite this aggressive regimen, the median survival remains approximately 14 months. Thus, meaningful strategies for therapeutic intervention are desperately needed.
Source: InTech eBooks
DOI: 10.5772/53387
Authors: Pouya Jamshidi, Clark C.
Language: English
Subfield: Genetics (clinical)
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W1531400814