Work

Proofreading function associated with the RNA-dependent RNA polymerase from influenza virus.

Year: 1986

Type: article

Abstract: The influenza virus-associated RNA polymerase cleaves capped RNA in an endonucleolytic manner and the transcription is initiated by the addition of GMP, the first substrate to be polymerized under the direction of viral RNA template, onto 3'-termini of resulting capped RNA fragments. In the presence of high concentrations of GTP as a sole substrate, multiple GMP residues were polymerized onto the primers. By the addition of the second substrate CTP, excess GMP residues, other than the 1st residue, were removed prior to elongation. The result may suggest that the RNA-dependent RNA polymerase carries a proofreading function.

Source: Journal of Biological Chemistry

DOI: 10.1016/s0021-9258(18)67540-4

Authors: A Ishihama, K Mizumoto, K Kawakami, A Kato, A Honda

Institutions: National Institute of Genetics, Jichi Medical University, The University of Tokyo

Language: English

Topic: Influenza Virus Research Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

Open Access status: hybrid

Estimated APC paid: $3,430

OpenAlex ID: W1532040581

FWCI: 0.689

Cites: 18

Cited by: 54

Related to: 10