Year: 1999
Type: dissertation
Abstract: Diabetes mellitus comprises a clinically and genetically heterogeneous group of\ndisorders that have one common feature: abnormally high levels of glucose in\nthe blood. The most common form is non-insulin dependent diabetes mellitus\n(NlDDM); about 80-90% of all diabetic patients has NlDDM. Other forms of diabetes\nare insulin-dependent diabetes mellitus (lDDM) and gestational diabetes.\n• In 1985, the World Health Organization (WHO) defined new criteria for diabetes\nmellitus based upon the oral glucose tolerance test (OGIT). During the\nOGIT test the fasting glucose level is measured, followed by the measurement of\nthe glucose level, 2 hours after an intake of 75 g glucose. Depending on whether\nthe glucose levels have been measured in the blood, plasma or serum, cut-off\nvalues have been defined. Three diagnoses can be made: normal glUcose\ntolerance, impaired glucose tolerance (IGT) or diabetes mellitus.\nThe OGIT is often used in epidemiological research. However, in clinical\npractice, the diagnosis diabetes is usually based on the presence of the classic\nsymptoms of diabetes (polyuria, hunger, thirst, weight loss, tiredness) combined\nwith a single abnormal blood glucose level, or on two abnormal levels without\ncomplaints measured on different occasions.
Author: Caroline A. Baan
Institution: Erasmus University Rotterdam
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1533331587