Modulation of pro-inflammatory cytokines in normal and inflamed skin
Year: 2001
Type: dissertation
Abstract: This thesis describes the expression and modulation of pro-inflammatory cytokines in\\nnormal and inflamed skin. During the last few decades it has become clear that the skin comprises\\na complex network of interacting cells including keratinocytes (KC). dendritic cells\\n(such as Langerhans cells: LC). macrophages. endothelial cells. fibroblasts and T cells.\\nDuring an infectional or trauma incident. resident and invading cells in skin initiate a complex\\ncascade of events resulting in an inflammatory reaction and ultimately in the elimination\\nof the infectious agent or recovery of the wound. Pro-inflammatory cytokines like members\\nof the interleukin-1 (IL-l) fantily of proteins. tumor necrosis factor-a (TNF-a) and IL-6 play\\na prominent role in the induction and maintenance of this inflammatory response. When the\\nexpression of cytokines in skin is altered. it can result in an inflammatory disease like psoriasis.\\nThus the regulation of cytokine expression must be tightly orchestrated. The regulation\\nof pro-inflanunatory cytokines in normal and inflamed skin is still incompletely understood.\\nDuring the study presented in this thesis the modulation and effects of pro-inflanunatory\\ncytokines in skin were investigated. This introduction is focussed on the expression of these\\npro-inflammatory cytokines. The following paragraphs deal with the architecture of the skin.\\nthe interaction and cross talk of the cells residing in it and the expression and regulation of\\nthe IL-l family of proteins.
Author: Arjen Companjen
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W1533338315