Estimation Efficacy of Antithrombotic Activity of Various Antiplatelet Drugs in Murine Model
Year: 2013
Type: article
Abstract: Objective: To estimate antithrombotic effect of antiplatelet drugs, in collagen epinephrine treated swiss mice. Materials and Methods: Lung damage (pulmonary thromboembolism) in swiss mice treated with collagen (1.5 mg/kg) and epinephrine (0.5 mg/kg) by tail vein was studied by assessing parameters such as percentage protection. The effect of antiplatelet drugs (30µM oral) on above parameters was investigated .This biochemical observations were supplemented by histological examination of lung sections. The data from the dose response studies were subjected to one-way ANOVA followed by post hoc Bonferroni's Multiple Comparison test. Results: Administration of antiplatelet drugs (30µM oral) significantly increased percentage protection against collagen epinephrine induced pulmonary thromboembolism. Histological examination of lung sections revealed less thrombi generation, after administration of various antiplatelet drugs. Conclusions: The study suggests preventive action of antiplatelet drugs in collagen epinephrine induced pulmonary thromboembolism.
Author: Sharma, Abhishek
Institution: Bhupal Nobles University
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1533452984