Work

Rationale, Instrumental Accuracy, and Challenges of PET Quantification for Tumor Segmentation in Radiation Treatment Planning

Year: 2012

Type: book-chapter

Abstract: Rationale, Instrumental Accuracy, and Challenges of PET Quantification for Tumor Segmentation in Radiation Treatment Planning 29 between PET-derived GTV and CT-derived GTV are performed without intravenous (IV) contrast.The routine use of IV contrast during PET/CT is expected to enable the clinician in further refining the GTV (Haerle et al., 2011).Ideally, drawing target contours with an accuracy of the order of 1 mm is desirable to match the precision of contemporary dose delivery.While this is achievable with CT and MRI, it is still a challenge for PET.Lastly, GTV is also derived based on clinical examination.Because all imaging modalities (PET, CT, or MRI) have limitations in defining mucosal involvement, the value of a physical examination by a radiation oncologist cannot be underestimated.Currently, due to the limited resolution of PET and its poorly known quantification accuracy, defining the target for radiation therapy by segmenting PET images is problematic.For this reason, it is important to understand and try to minimize the potential image degrading factors for each patient PET scan (Kang et al., 2009).

Source: InTech eBooks

DOI: 10.5772/31839

Authors: Assen S., C. Ross, Hyejoo Kang, Nancy Lee

Institutions: Memorial Sloan Kettering Cancer Center, Northwestern Memorial Hospital

Language: English

Topic: Medical Imaging Techniques and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Bucknell University, Memorial Sloan-Kettering Cancer Center, McGill University