Antitumor and structure antioxidant activity relationship of colchicine on Ehrlich ascites carcinoma (EAC) in female mice
Year: 2014
Type: article
Abstract: Colchicine has been reported to play important roles in hepatoprotection, anti-inflammation in vitro anti cancer activity.The present study was initiated to evaluate antioxidant and anti-cancer effects of colchicine (10øg/mice, i.p.) in mice after subcutaneous implantation of ehrlich ascites carcinoma (EAC) for 21 days.On the 22 th day, the mice were sacrificed for the estimation of tumor growth, and biochemical parameters (glucose, insulin, alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), lipid peroxides (TBARS), protein thiols (Pr-SHs), reduced glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPx), total cholesterol (TC), triglycerides (TG), HDL-C, LDL-C, 17β-estradiol and progesterone).The results of this study showed that administration of colchicine and 5-Flourouracil individually for 21 days to the carcinoma induced mice demonstrated a significant (P<0.01)decrease in tumor weight and a significant (P<0.01)improvement in biochemical parameters and life span compared to the EAC control mice.In addition, the results clearly suggest that colchicine induced antioxidant activity on experimental EAC control mice.
Authors: Mohammed A. Hussein, Sylvia A. Boshra
Institution: October 6 University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W1533790080