Year: 2015
Type: review
Abstract: Brain-implanted devices are no longer a futuristic idea. Traditionally, therapies for most neurological disorders are adjusted based on changes in clinical symptoms and diagnostic measures observed over time. These therapies are commonly pharmacological or surgical, requiring continuous or irreversible treatment regimens that cannot respond rapidly to fluctuations of symptoms or isolated episodes of dysfunction. In contrast, closed-loop systems provide intervention only when needed by detecting abnormal neurological signals and modulating them with instantaneous feedback. Closed-loop systems have been applied to several neurological conditions (most notably epilepsy and movement disorders), but widespread use is limited by conceptual and technical challenges. Herein, we discuss how advances in experimental closed-loop systems hold promise for improved clinical benefit in patients with neurological disorders.
Source: JAMA Neurology
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
Funders: National Science Foundation, March of Dimes Foundation, Citizens United for Research in Epilepsy, National Institutes of Health, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: HIPPOCAMPAL INTERNEURONAL NETWORK, Towards a Complete Description of the Circuitry Underlying Memory replay., G1872289060, GABAergic regulation of entorhino-hippocampal excitability in epilepsy, The Temporal Dynamics of Learning, G5318893862, G6172037519, G6731844918, Deducing the origin and effect of extracellular electric fields in hippocampus, On-demand optogenetic cerebellar intervention for temporal lobe epilepsy, Pediatric Scientist Development Program, G977327898
OpenAlex ID: W1534009784