Pharmacology of organoselenium compounds: Emphasis on puzzling mechanistic switching from their glutathione peroxidase mimic in vivo
Year: 2012
Type: article
Abstract: Organoselenium compounds are a new class of emerging potent antioxidants.Basically, their rational design and synthesis was aimed at mimicking the native glutathione peroxidase enzyme in their reduction of hydroperoxides at the expense of the ubiquitous antioxidant, glutathione.In this review, emphasis was focused on the seemingly antagonistic mechanisms employed by organoseleniums under in vitro and in vivo conditions.Summarily, in vitro evidences clearly demonstrate that the pharmacological effect of organoseleniums strictly depends on their GPx mimic.However, these selenium based compounds evoke an increase in the level of endogenous thiols suggesting a possible switch in their glutathione peroxidase mimic under in vivo conditions.Apparently, this mechanistic switch is puzzling and requires concerted efforts to unravel.
Authors: Kade, Ige J., da Rocha, Joao B. Teixeira
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
Funders: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Consejo Nacional de Ciencia y Tecnología, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul, Financiadora de Estudos e Projetos, Universidade Federal de Santa Maria, Universidade Federal do Rio de Janeiro
OpenAlex ID: W1535026936