Year: 2015
Type: letter
Abstract: ALT/GPT levels between the different PNPLA3 genotypes.Significant differences in ALT/GPT levels between CC vs. GG were confirmed (CC = 26.5 Æ 14.1; CG = 34.7 Æ 27.2; GG = 43.9Æ 32.5; CC vs. CG: P = 0.1; CG vs. GG: P = 0.364; CC vs. GG: P = 0.002).The same was shown for a PNPLA3-dependent ALT/ GPT level analysis in overweight/obese patients with metabolic syndrome (CC = 35.73Æ 16.30; CG = 46.34Æ 29.82; GG = 60.22 Æ 37.13; CC vs. CG: P = 0.034; CG vs. GG: P = 0.237; CC vs. GG: P = 0.002).Moreover, overweight/obese subjects without metabolic syndrome were within normal ranges of ALT/GPT (ALT/GPT 29.9 Æ 20.6 in patients without metabolic syndrome vs. 42.1 Æ 25.5 with metabolic syndrome; ttest P = 0.00002), and had a De Ritis quotient >1 (De Ritis 1.2 Æ 0.5 without metabolic syndrome vs. 0.8 Æ 0.3 with metabolic syndrome; t-test P = 0.003), which contradicts the presence of NAFLD in these patients.Thus, we conclude that the published results are valid, and show that there is a strong association between PNPLA3 genotype and ALT/GPT levels in overweight and obese patients irrespective of the presence of NAFLD.
DOI: 10.1111/apt.13303
Authors: D. Y. Graham, J. P. Gisbert
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W1535538782