Year: 2014
Type: review
Abstract: Experimental techniques that interface single biomolecules directly with microelectronic systems are increasingly being used in a wide range of powerful applications, from fundamental studies of biomolecules to ultra-sensitive assays. In this study, we review several technologies that can perform electronic measurements of single molecules in solution: ion channels, nanopore sensors, carbon nanotube field-effect transistors, electron tunneling gaps, and redox cycling. We discuss the shared features among these techniques that enable them to resolve individual molecules, and discuss their limitations. Recordings from each of these methods all rely on similar electronic instrumentation, and we discuss the relevant circuit implementations and potential for scaling these single-molecule bioelectronic interfaces to high-throughput arrayed sensing platforms.
DOI: 10.1002/wnan.1323
Institutions: Brown University, University of Twente, Columbia University
Language: English
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: bronze
Awards: G1261373819, G143808173, G2030458809, High-bandwidth, single-molecule bioelectronics using a multiplexed, field-effect sensing platform, Single Molecule Real Time Electronic Sequencing, Studies of Riboswitch-Mediated Transcriptional Control Using Single-Molecule Fiel, G9000004481, G9000064303, G9000154722, G9000262219
OpenAlex ID: W1536122306