Year: 2007
Type: report
Abstract: The P582S C->T and A588T G->A polymorphisms in the Hypoxia-inducible factor-1alpha (HIF-1alpha) gene have been associated with enhanced stability of the protein and androgen-independent prostate cancer (CaP). Methods: We examined the association of these polymorphisms with CaP among 1,072 incident cases and 1,271 controls, and further explored their joint associations with various prediagnostic plasma hormone levels. Results: The A588T polymorphism was too rare to provide meaningful conclusions and the P582S polymorphism was not associated with CaP. We observed a significant interaction of the P582S genotype with insulin-like growth factor binding protein (IGFBP)-3 in modifying CaP risk such that higher IGFBP-3 levels (>= versus <median) were associated with a reduced risk only among men with the wildtype (OR, 95% CI = 0.74, 0.57-0.97; (Pinteraction) = 0.01). Conclusions: We found no association between these HIF-1alpha gene polymorphisms with CaP, but the interaction between the P582S polymorphism and the IGF axis merits further evaluation in mechanistic studies
DOI: 10.21236/ada470130
Author: Glenn Bubley
Institutions: Beth Israel Deaconess Medical Center, Harvard University
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
Funder: National Institutes of Health
OpenAlex ID: W1536884906